Low Oxygen While Sleeping

Woman with oxygen mask

It is normal for blood oxygen levels to decrease during sleep. However, when it persistently drops below maintenance levels, health problems can develop. In addition, certain medical conditions can lead to low oxygen while you are asleep.

Oxygen Level During Sleep

All body systems have altered basal function during your sleep, including breathing. You don't breathe as deeply when you are sleeping, and not all your lung spaces (alveoli) function at full capacity. Because of this effect of sleep on breathing, it is normal for your sleep oxygen level to decrease below awake levels, according the Respiratory Care.

Under normal conditions, oxygen levels during sleep are maintained in a normal range. However, certain medical problems can lower your blood oxygen below normal levels, and this effect can worsen during your sleep. This can present a real risk for sudden death if not treated. Chronic low blood oxygen level (hypoxemia) at night can also lead to health problems.

Medical Disorders

According to the Mayo Clinic, certain medical problems, especially of the cardiovascular and respiratory systems, can lead to blood oxygen below normal levels. The effects of these conditions can worsen while you are sleeping. The most common disorders include:

  • Diseases of the lungs: Several lung diseases can narrow or block lung air spaces, inflame or scar lung tissue, and can also interfere with normal breathing pattern. These lung diseases include:
  • Heart diseases: Disorders of the heart, which can interfere with blood flow, blood oxygen level, and oxygen supply to tissues include:
  • Anemia: The decrease in hemoglobin (Hgb) with anemia lowers the ability of your red blood cells to absorb oxygen from your lungs and carry it to your tissues. Abnormal Hgb, such as with sickle cell anemia, causes the same problem.
  • Obesity: This a cause of sleep apnea where the throat becomes obstructed during sleep and interferes with breathing. Obesity also causes obesity hypoventilation syndrome (OHS), with diminished deep breathing and oxygen intake.
  • Drugs: Chronic use of prescription or illegal opioids, sedatives, and recreational or other illegal drugs can depress the brain's breathing center and therefore slow down your breathing and oxygen intake.
  • Alcohol: Abuse of alcohol, especially at bedtime and mixed with drugs, can interfere with normal breathing and sufficient oxygen intake.
Woman can?t sleep

Health Consequences

A normal blood oxygen level is vital for normal tissue and cellular function. Therefore, low blood oxygen affects the function of every tissue in the body. A chronic problem of low oxygen levels while sleeping can increase the risk for several health consequences including:

  • Sleep disorders, such as bouts of insomnia
  • Poor sleep quality, such as restless sleep with several awakenings
  • High blood pressure
  • Cardiovascular disease including heart failure
  • Cardiac arrythmia and a risk for sudden death
  • Type 2 diabetes
  • Depressed brain function and possible brain damage
  • Risk for loss of conciousness, coma, and death

Signs and Symptoms of Nighttime Hypoxemia

Persistence in low oxygen while you sleep can cause the following recurrent, chronic symptoms:

  • Waking up choking or coughing
  • Waking up gasping for air
  • Snoring and restlessness during sleep witnessed by others
  • Daytime drowsiness and decrease in alertness
  • Dizziness
  • Shortness of breath
  • Lack of energy, extreme fatigue, and weakness
  • Diminished ability to function during the day
  • Confusion and disorientation
  • Poor memory or memory loss
  • Anxiety and depression

Measuring Blood Oxygen

According to the University of California San Francisco (UCSF), doctors assess oxygen levels in blood by one of two ways:

  1. Pulse oximetry: The hemoglobin of your red blood cells absorbs the oxygen from your lungs. Pulse oximetry measures how saturated your red blood cells are with oxygen. The test is done with a small device clipped on to your finger or earlobe.
    • Normal oxygen saturation (O2 sat) is 98 to 100%
    • Low O2 sat is less than 90%
  2. Arterial blood gas (ABG): Measures the amount of oxygen dissolved in the blood. The test is done by drawing blood from an artery and analyzing it in the lab.
    • Normal arterial oxygen or arterial oxygen pressure (PaO2) is 80 to 100 millimeters of mercury (mm Hg)
    • Abnormal PaO2 is less than 60 mm Hg

Overnight Oximetry Study

If you think your oxygen level falls below normal while you are sleeping, consult with your doctor. He might suggest a sleep study as part of your evaluation. During an overnight stay in a sleep center, a technician monitors your breathing and other signs, as well as your blood O2 sat with a pulse oximeter during sleep.

Oxygen tank and mask


According to the UCSF reference, the treatment for low blood oxygen, whether during the day or while sleeping, is supplemental oxygen. Your doctor determines how many liters per minute of oxygen you need to keep your blood O2 sat at or above 90%. Your doctor will recommend the equipment you need for oxygen therapy, which can be obtained from manufacturers like Philips Respironics.

Treatment with supplemental oxygen will be in addition to the treatment of any underlying cause of the sleeping hypoxemia. If sleep apnea is the cause of your low oxygen, the doctor will likely prescribe a continuous positive airway pressure (CPAP) machine and supplies to keep your breathing airways open during sleep.

Monitoring Treatment

Symptoms like fatigue, shortness of breath, lethargy and weakness should improve soon after you start treatment. How long you continue on oxygen therapy will be determined by your doctor and based on the cause of your low oxygen while asleep and your response to treatment.

Your doctor or respiratory therapist might periodically check your O2 sat on occasion to make sure it is in normal range on supplemental oxygen. You can also buy a pulse oximeter online from a medical supplier and monitor your O2 sat yourself.

Lifestyle Adjustments

It is important to adjust any lifestyle habits that might be contributing to your low oxygen level or risk for worsening of your problem. These habits include:

  • Alcohol abuse
  • Prescription or illegal drug misuse or abuse
  • Combining alcohol with drugs or using multiple drugs
  • Smoking
  • Poor eating habits and a sedentary lifestyle, which increase the risk for obesity and sleep apnea

Don't Wait to See Your Doctor

Low oxygen in your blood while you sleep can affect the function of your vital organs, such as your brain, heart, liver, and kidneys. This puts you at risk for dying during your sleep from malfunctioning of these and other organs. Don't wait to see your doctor if you suspect hypoxemia while sleeping.

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Low Oxygen While Sleeping